Given our increasing knowledge regarding the roles of incretin biology [30] and microbiome [31] on intermediary metabolism as well as the proven effects of alpha-glucosidase inhibitor, a compound sharing similar actions as guar gum, in preventing diabetes in subjects with IGT [7], long-term use of galactomannan has the potential to stall progression to diabetes in at-risk individuals. The gene discussed is GCG; the disease is diabetes mellitus.