MMPs are a family consisting of 23 protein members that could be involved in the degradation of osseous tissue and other extracellular matrices in the human body.[11] It was reported that MMPs were key regulators of tissue degradation and remodeling.[11] They were revealed as participating in the nosogenesis of several diseases of synovial joints such as rheumatoid arthritis (RA), osteoarthritis (OA), and AS.[12] Several studies showed that AS was associated with high levels of MMP-3.[13,14]MMP-8 is the member of MMPs. This evidence concerns the gene MMP3 and rheumatoid arthritis.