TCF4 and colorectal carcinoma: The alleles of rs6983267, differentially bind transcription factor 7-like 2 and physically interacts with the MYC proto-oncogene.[12] Another study found that rs6983267 also affects binding of the Wnt-regulated transcription factor TCF4 in a regulatory element, with the risk allele G showing stronger binding that is functional in CRC cells.[13] These data provide strong support for a biological mechanism underlying 8q24 variants in genesis of colonic neoplasia.