In the Diabetes Prevention Program (DPP), a cohort of US participants (n = 3,534) with impaired glucose tolerance at baseline and followed for incident diabetes, presence of KCNJ11 variants was associated with decreased insulin secretion at baseline; but, over the initial 3 years of follow-up, the presence of these variants was not associated with an increased risk of diabetes [33]. The gene discussed is INS; the disease is diabetes mellitus.