AKT2 ablation prolonged lifespan and improved cardiac aging through restored FOXO 1‐related autophagy and mitochondrial integrity (Ren et al., 2017), and chronic AKT activation accentuated aging‐induced cardiac hypertrophy and myocardial contractile dysfunction through a loss of autophagic regulation (Hua et al., 2011). The gene discussed is AKT1; the disease is cardiac hypertrophy.