We have detected the single exon 47 deletion in one subject of the controls cohort and in this subject, clinical investigation was negative for neurological involvement and he did not refer migraine; we cannot exclude a low penetrance of the deletion in this patient or that he will manifest clinical signs in the years to come.Further investigation and functional studies are necessary to better understand the role of CACNA1A exon 47 deletion in migraine disorders. The gene discussed is CACNA1A; the disease is migraine disorder.