AJ enriched CD risk alleles were observed in the well-established CD risk gene NOD2 and in the gene LRRK2. Furthermore, AJ CD cases and controls were found to have a greater CD polygenic risk score (incorporating 124 CD risk alleles but not those in NOD2 or LRRK2) compared with non-Jewish European individuals. The gene discussed is NOD2; the disease is Cowden disease.