NOD2 and atrial fibrillation: All of the other well-established NOD2 variants (Huang et al. 2017; Rivas et al. 2018) were identified in at least one family and their AF in the unrelated CD cases approximated to that in both the independent AJ case/control dataset and the literature (e.g., L1007insC/rs2066847 was observed at an AF of 0.075 in CD cases compared with 0.072 in CD cases in the AJ case/control dataset).