Further, TRIF (Ticam1−/−) null mice, lacking the TLR3-specific intracellular adaptor TRIF, are partially susceptible to HSE, where decreased IFNβ production at day 5 post intranasal HSV-1 infection was associated with 60% of mice developing lethal encephalitis by day 8 (Menasria et al. 2013). The gene discussed is TICAM1; the disease is viral encephalitis.