Neurons lacking key autophagy factor ATG5 (Atg5−/−) yield higher viral titers in culture, following infection with both a Beclin-binding domain-deficient and functional HSV-1 virus, suggesting that while ICP34.5 certainly reduces autophagy, autophagy can also be initiated at early time-points before ICP34.5 is expressed to help reduce viral load (Yordy et al. 2012). The gene discussed is ATG5; the disease is infection.