FOXO3 and posterior cortical atrophy: Our results also revealed an increase in AMP/ATP ratio in response to suppression of FABP5 and induction of apoptosis and cell cycle arrest through the AMPK-FOXO3A signaling pathway in PCa cells (Figure 7B), strongly suggesting that FABP5 regulates cell growth and mitochondrial functions that is essential for energy metabolism in PCa cells.