TAZ (WWTR1 is the gene) and YAP (YAP1 is the gene) are developmentally important transcriptional coactivators [1, 2] that have emerged as central oncoproteins in a number of carcinomas including breast [3, 4], colon [5], liver [6], lung [7, 8], pancreas [9], and thyroid cancers [10]. The gene discussed is YAP1; the disease is thyroid cancer.