rs7195994 is in LD with rs2540767 (r2 = 0.9), which shows chromatin interaction with the IRX3 gene [18] (Supplementary Figure 4b), which some studies have suggested is one of the causal genes for obesity/BMI at the FTO locus [24]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.