Interestingly, the imidazole-based H3R antagonists, namely, ciproxifan and clobenpropit, control the elevation of various oxidative stress markers, including MDA and GSH, in amphetamine- or dizocilpine-augmented oxidative stress in an experimental mice model of SCH, indicating that H3R antagonists possess antioxidant activity, which might serve the antioxidant needs of SCH and at the same time control the symptomatic features of SCH75,76. This evidence concerns the gene HRH3 and spindle cell hemangioma.