The other indices tested in this study (APRI, Frons’ index, FIB-4, S-index) may be less reliable than PSR because they rely on multiple serum and biochemical parameters (e.g. AST, ALT, GGT), which may vary with many factors such as blood drawing time, sample delivery time, cancer treatment, tumor size, and liver functional status. This evidence concerns the gene GPT and neoplasm.