To compare the different aspects of autoimmune hyperthyroidism and associated orbitopathy at its whole the data sets characterizing autoimmune hyperthyroidism (TSAbs, T4 values and thyroid area) and orbitopathy investigated by MRI (Fat volume, 19F Integral, CEST Contrast) or by histology (F4/80, CD3, muscle fiber, UCP-1, collagen) were normalized by using the Z-Score method. The gene discussed is UCP1; the disease is Graves disease.