In addition, indole-3-carbinol (I3C) and 3, 3′-diindolylmethane (DIM) improve the expression of IL-10 and the percentages of Treg cells in peripheral blood of mice with delayed hypersensitivity reaction by inhibiting expressions of miR-31, miR-219 and miR-490 in guinal lymph node cells20; tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming by activating AhR24. This evidence concerns the gene IL10 and type IV hypersensitivity disease.