Constitutive Wnt signaling, triggered by inactivation of the tumor suppressor gene APC, followed by mutations in codons 12 and 13 of the KRAS oncogene, characterize the traditional CRC pathway originating from tubular adenomas (TAs), villous adenomas (VAs) and mixed tubulovillous adenomas (TVAs)2. This evidence concerns the gene APC and colorectal carcinoma.