KRAS and neoplasm: In case H263, the neoplasia harbored two KRAS mutations: 3 out of 5 sequenced regions were positive for the c.35G>A/G12D mutation at 5–31% frequencies, and 4 out of 5 regions were positive for the c.38G>A/p.G13D mutation at 16–34% frequencies (Fig. 4c).