Therefore, we speculated that SNHG5 may mediate HCC cell process by interacting with miR-26a-5p, and through luciferase reporter and qRT-PCR assay, we found that SNHG5 directly binds to miR-26a-5p and there was an interactive suppression between them. The gene discussed is SNHG5; the disease is hepatocellular carcinoma.