For instance, lncRNA MEG3 promotes the proliferation of glioma cells through targeting Wnt/β-catenin signal pathway;38 lncRNA PLIN2 promotes the development of chronic myelogenous leukemia via the GSK3 and Wnt/β-catenin signaling pathways39. This evidence concerns the gene MEG3 and chronic myelogenous leukemia, BCR-ABL1 positive.