The results showed cell proliferation of HepG2 and MHCC-97L cell lines was reduced when SNHG5 knockdown compared with NC and inhibitor NC group, cell growth was promoted when miR-26a-5p inhibition, however, the inhibitory effect of SNHG5-shRNA on HCC cell growth could be partially restored by miR-26a-5p inhibitor (Fig. 6a). Here, SNHG5 is linked to hepatocellular carcinoma.