To prove that the trehalose-induced mitophagy correlates with apoptotic capability of cancer cells, we analysed the impact of the intrinsic apoptotic pathway and its correlation with mitochondria dynamics, analysing the effect of trehalose and rapamycin on docetaxel-induced cytochrome c release, activation of caspase-9, caspase-3 and the cleavage of PARP. This evidence concerns the gene CASP3 and cancer.