MRE11 and neuroblastoma: A large fraction of aggressive and MYCN-driven neuroblastomas is associated with a specific signature impinging on DNA replication, DNA repair, and cell cycle regulators32,50, suggesting that this gene expression program, which includes transcriptional regulation of MRE11 (ref.26), might be pivotal to increase cell tolerance to RS and its related DNA damages in MYCN-driven tumors.