Spehalski et al.46 reported that Mre11 deficiency prevented tumorigenesis in mouse p53−/− B-cell lymphoma models associated with oncogenic translocations involving Myc genes, indicating that MRE11 (and by extension the MRN complex) cannot be considered a standard tumor suppressor since its activity is required for cancer development. Here, TP53 is linked to B-cell non-Hodgkin lymphoma.