An imbalance between pro- and anti-apoptotic genes favoring the latter has been demonstrated in melanoma cells by increased expression of RelA, p50, anti-apoptotic molecules (such as inhibitor of apoptosis (IAP) and caspase-8 inhibitory protein (FLIP)), and decreased expression of c-Rel, a pro-apoptotic regulator [186]. This evidence concerns the gene NFKB1 and melanoma.