Interestingly, Ptpn14 is a negative regulator of Yap (Liu et al., 2013) and Yap is essential for nephron induction and differentiation (Reginensi et al., 2013), and its subcellular localization is dysregulated in Wilms tumor (Murphy et al., 2014). This evidence concerns the gene PTPN14 and Nephroblastoma.