DNMT1 and Beckwith-Wiedemann syndrome: Case B66 with the variant DNMT1 NM_001130823.1: c.3668G>A, NP_001124295 p.Arg1223His, was a female conceived by intracytoplasmic sperm injection, and she also had a greater number of the clinical features of BWS when compared with the other two cases (five versus three in the other DNMT1 variant cases).