MTHFR and coronary artery disorder: Although many studies have indicated that MTHFR C677T and MTHFR A1298C are not strongly related to the risk of CHDs [18, 23, 24], in two recent meta-analyses, Li et al. evaluated 19 eligible studies concerning the MTHFR C677T polymorphism and CHD, comprising 4219 cases and 20,123 controls.