Although poor appetite is probably a major cause of malnutrition, it is mediated by a variety of factors such as age, several peptide hormones released by the gut including; ghrelin, CCK, peptide-YY, glucagon-like peptide 1, oxyntomodulin, and pancreatic polypeptide and many neurotransmitters [58–61]. Here, GHRL is linked to nutritional deficiency disease.