Therefore, not only imbalances associated with the upregulation of studied markers in T and B cells during HIV-1+ infection, but also the dysregulation of relationship between the costimulatory markers CD72 and PD-1 and the production of a pro-inflammatory cytokine on T cells were observed, which may be a very important part of the dysregulation of immune system homeostasis and hyper-activation. This evidence concerns the gene CD72 and infection.