TNF and tuberculosis: Given the plasticity of macrophage responses [15] and the opposing effects that TNFα may have on neutral lipid accumulation (e.g., TNFα reduces the lipid content of adipocytes by lipolysis [34, 64, 65], and it induces liver steatosis by stimulating lipid biosynthesis in hepatocytes [66, 67]), our work does not exclude the possibility that TNFα also induces lipolysis in lesional macrophages during tuberculosis.