Immunostained samples demonstrated predominant junctional N-cadherin localization in myocardium, in both the PLEC negative (group 1) and PLEC positive (group 2) ARVC patients (PLEC negative TFC+ patients, diagnostic score 3.3 ± 0.2 [normal]; PLEC positive TFC+ patients, diagnostic score 2.9 ± 0.4 [normal]). This evidence concerns the gene CDH2 and arrhythmogenic right ventricular cardiomyopathy.