In addition, the loss of co-localization of plectin and desmin at the Z-discs and intercalated disc, together with desmin and plectin aggregate formation, observed in the heart of the patient with EBS-MD and DCM indicates that plectin plays an important role in the structural organization of the desmin network and in providing mechanical support [14]. Here, PLEC is linked to familial dilated cardiomyopathy.