PNPLA3 and Cirrhosis: Table 5 summarizes the frequencies of each variant in these groups. The findings of our study suggest that neither of the two polymorphisms affects the risk of cirrhosis (PNPLA3 P = 0.27, TM6SF2 P = 0.92) or the odds of requiring liver transplantation (PNPLA3 P = 0.66, TM6SF2 P = 0.77) in PSC patients with concomitant ulcerative colitis.