TGFB1 and Hepatic fibrosis: Recent reports have demonstrated that ncRNAs participate in modulating numerous biological functions and pathological processes through regulating gene expression at the transcriptional and posttranscriptional levels.40, 41 For instance, a recent study has reported that the liver-enriched lnc-LFAR1 promotes hepatic stellate cell activation and TGFβ-induced hepatocyte apoptosis in vitro and aggravates both CCl4- and bile duct ligation-induced liver fibrosis by activating the TGF-β and Notch pathways.12