Also, it has been demonstrated that ciRS-7 can repress Alzheimer’s disease (AD) development by suppressing NF-κB protein synthesis and inducing its cytoplasmic localization, promoting UCHL1 expression and UCHL1-induced amyloid precursor protein (APP) and BACE1 ubiquitination and degradation.13 Here, UCHL1 is linked to early-onset autosomal dominant Alzheimer disease.