JAKMIP3 and Insulin resistance: Finally, in order to get insights into the mechanisms regulating NECC2 expression in adipose tissue, we assessed the expression of this protein in in vitro models of adipocyte hypertrophy and/or insulin resistance.26, 59, 60 We observed that induction of insulin resistance by exposure to HGHI significantly increased NECC2 protein levels, which is in accordance with the changes observed in human adipose tissue.