INS and obesity due to melanocortin 4 receptor deficiency: These results are in line with previous observations from our laboratory and other groups indicating that different insults operating in obesity (ie cytokines, lipids, glucose) may activate distinct subcellular responses in adipocytes.26, 59, 60 In this scenario, it is tempting to speculate that the up‐regulation of NECC2 observed in insulin‐resistant obese individuals results from the activation of obesity‐triggered cellular stress responses.