The absence of AIM2 in melanoma promoted the cell migration, invasion and disease progression.11 The restricted proliferation of cancer cells by over‐expressing AIM2 was found in colon cancer,12, 13, 14, 15 breast cancer16, 17 and prostate cancer.18 Thus, these results suggest that AIM2 plays an important role in the development and progression of cancer with decrease or deficiency of AIM2. The gene discussed is AIM2; the disease is cancer.