AIM2 and renal cell carcinoma: Folate‐grafted PEI600‐CyD (H1) as a non‐viral gene delivery vehicle can effectively condense plasmid DNA to form stable functionalized nanoparticles.25 Recent studies have shown a significant success using H1 to deliver genes in vivo.26 More importantly, H1‐based delivery system leads to neither elevate enzymes in serum nor a non‐specific immune response in mice, suggesting its low toxicity.25, 26 Therefore, H1‐based plasmid AIM2 (pAIM2) nanoparticles may be a therapeutic strategy for RCC treatment.