The CARD of ASC binds the CARD of pro‐caspase‐1 to lead to caspase‐1 activation and the production of interleukin‐1β (IL‐1β) and IL‐18 through cleavaging the pro‐IL‐1β and pro‐IL‐18.8 The activation of AIM2 inflammasome regulating inflammatory response is well explored in innate immune cells.7, 8, 9, 10 Currently, AIM2 as a tumour suppressor is remarkably interest in cancer. Here, IL18 is linked to cancer.