To identify novel anticancer compounds against RCC, we isolated fractions from the extracts of Artemisia annua L. (Figure 1A) that exhibited potent cytotoxic activity in human RCC lines [Caki‐1 (wild type von Hippel‐Lindau) (VHL) and 786‐O (VHL null with constitutive HIF activity)] (Figure 1B). This evidence concerns the gene VHL and renal cell carcinoma.