Consistent with the inhibitory action of MC‐4 on PKM2 expression in vitro, significant reduction in PKM2‐positive cells was observed in vivo by MC‐4 treatment (Figure 3B), indicating that MC‐4 induces autophagy against RCC possibly through the inhibition of cancer cell glucose metabolism modulated by Akt/PKM2. This evidence concerns the gene AKT1 and cancer.