Expression profiling of coding transcripts following HOTAIR knockdown in HCC cells resulted in the dysregulation of 296 genes, including upregulation of QKI, KH domain containing RNA binding (QKI), CD82, and RNA binding motif protein 38 (RBM38); increased transcript and protein levels of these three genes were further validated by qRT-PCR analysis and western blotting, respectively [46]. The gene discussed is RBM38; the disease is hepatocellular carcinoma.