There were significant differences across SLE, RA, and pSS, such as IL6R (P = 5.65E − 79), KLF10 (P = 2.69E − 75), NR1H3 (P = 6.05E − 73), CMTM4 (P = 1.69E − 68), CD164 (P = 3.37E − 59), TNFRSF21 (P = 3.63E − 51), and STAT3 (P = 2.26E − 49). This evidence concerns the gene NR1H3 and systemic lupus erythematosus.