Lymphotoxin beta receptor (LTβR), a member of the tumor necrosis factor receptor superfamily, was reported to be associated with chronic inflammation diseases such as viral encephalitis [33], hepatitis B [34], IgA nephropathy [35], lymphoblastic leukemia [36], and type 1 diabetes [37] and plays a critical role in immune response and initiation of inflammation. Here, LTBR is linked to hepatitis B virus infection.