It is remarkable that AZU1 and VCAM1 (Figure 4) hypomethylated in their genes presumably combine their partners (e.g., chemokines and adhesion receptors) to trigger vasculitis that can be observed in most of autoimmune conditions including RA and SLE [30, 59, 60]. The gene discussed is AZU1; the disease is systemic lupus erythematosus.