However, contrary to what was mentioned above, some studies found that soluble α-Klotho levels had no significant correlation with eGFR [17–19] or even two studies reported α-Klotho were higher in patients with CKD [31, 36], we performed this review and meta-analysis to assess the correlation between soluble α-Klotho levels and renal function in patients with CKD. The gene discussed is KL; the disease is chronic kidney disease.