An upregulation of TLR4 has been observed in vascular endothelial cells in response to renal ischemia reperfusion injuries, and an increase in co-localization of TLR4 and vascular endothelial cells was observed in response to subarachnoid hemorrhages (Zhao et al., 2014; Zhang et al., 2015). The gene discussed is TLR4; the disease is subarachnoid hemorrhage.