PTGS2 and primary effusion lymphoma: Our studies demonstrated that HHV-8 utilizes arachidonic acid (AA) pathway enzymes (cyclooxygenase-2; COX-2, 5-lipoxygenase; 5-LO, leukotriene A4 hydrolase; LTA4H) and its metabolites (prostaglandin E2; PGE2, leukotriene B4; LTB4) in their life cycle, especially in the maintenance of its latency, and effective inhibition of these pathways could potentially be used in treatment to control KS/PEL [79–82].