Otherwise, we assesed the effect of mutant BRAF on the secerotry phenotype of melanoma cells by evaluating the expression of Interleukin 8 (IL-8) and transforming growth factor beta (TGF-β) that are angiogneic factors know to be overexpressed and involved in melanoma progression [32, 33]. This evidence concerns the gene TGFB1 and melanoma.