EZH2 and diffuse large B-cell lymphoma: Furthermore, an inhibitor of EZH2 methyltransferase activity, GSK126, resulted in reduction of H3K27 methylation levels in vitro and in vivo, and inhibited growth of EZH2-mutated diffuse large B-cell lymphoma (DLBCL) mouse xenografts and proliferation of EZH2-mutated DLBCL cell lines [3].