However, the amount of active caspase-3 (an indicator of apoptotic cell death) in immunoblots and immunostained tumor sections of tumors grown in Cd38‒/‒ mice was significantly higher than in WT mice (Figure 2E and 2F), suggesting that loss of CD38 in the TME promoted cell death, which in turn reduced tumor size. The gene discussed is CD38; the disease is neoplasm.