To examine the effect of loss of CD38 at an earlier stage and to avoid possible size-dependent effects, we next assessed tumorigenic features in size-matched tumors (average volume 140 mm3) obtained at earlier time points after tumor cell implantation (average 14.8 and 18 days post-injection for WT and Cd38‒/‒ mice, respectively). The gene discussed is CD38; the disease is neoplasm.