TNF and atherosclerosis: Fourth, we absolutely disagree that “high-sensitivity C-reactive protein, the telomere length, lipid oxidation products (MDA-modified collagen, type IV IgM and IgG antibodies), hyperuricemia, TNF-alpha, and IL-15 polymorphism” are “more specific risk factors for atherosclerosis”; the main concern for these metrics is just their low specificity; that is why they are still not either recommended or widely used as the confirmed risk factors of atherosclerosis.