CDK2 and lung cancer: More important, it is also found that miR-30a could regulate cell cycle through targeting IGF1R in nonsmall cell lung cancer, and IGF1R overexpression can upregulate expression of CDK4/Cyclin D1 and CDK2/Cyclin A2 complex via Akt signaling pathway, and IGF1R silencing hinders S/G2 transition by inhibiting the expression of CDK2/Cyclin A2 complex through Akt signaling pathway.