Periodontal disease, yet another example of an inflammatory disease, has been linked to other potential disorders, such as cardiovascular disease, diabetes, and stroke, and a study by Choi et al. [44] has concluded that CORM-3 possesses anti-inflammatory activity against the periodontal-disease inducing the pathogen Prevotella intermedia. Upon the addition of CORM-3, HO-1 expression in LPS-exposed cells was enhanced. This evidence concerns the gene HMOX1 and diabetes mellitus.