RUNX3 and intrahepatic cholangiocarcinoma: ICC of C class harbors recurrent focal CNAs including deletions involving CDKN2A, ROBO1, ROBO2, RUNX3, and SMAD4, while those of M class harbor recurrent mutations in the genes frequently mutated in ICC, i.e., TP53, KRAS, and IDH1, as well as epigenetic regulators and genes in TGFβ signaling pathway.