NF2 and hepatocellular carcinoma: By ablation of genes in Hippo signaling pathways (Lee et al., 2010; Lu et al., 2010) or knocking out neurofibromatosis type 2 (Nf2) gene (Benhamouche et al., 2010) in mouse, the authors proposed that ICC and HCC may share the same progenitor cells since all surviving mice eventually developed both CCA and HCC.