Focusing on the genomic findings from all ICC studies discussed above, recurrent mutations of ICC are enriched in tumor suppressor genes, i.e., ARID1A, ARID1B, BAP1, PBRM1, TP53, STK11, and PTEN, and oncogenes, i.e., IDH1, IDH2, KRAS, BRAF, and PIK3CA. The frequencies of these recurrent mutations in ICC across multiple studies are summarized in Figure 1. This evidence concerns the gene PIK3CA and intrahepatic cholangiocarcinoma.