Focusing on the genomic findings from all ICC studies discussed above, recurrent mutations of ICC are enriched in tumor suppressor genes, i.e., ARID1A, ARID1B, BAP1, PBRM1, TP53, STK11, and PTEN, and oncogenes, i.e., IDH1, IDH2, KRAS, BRAF, and PIK3CA. The frequencies of these recurrent mutations in ICC across multiple studies are summarized in Figure 1. The gene discussed is PBRM1; the disease is intrahepatic cholangiocarcinoma.