Because endothelial cells express CB1/CB2 receptors (52) and CBs elicit anti-inflammatory defense facing cytokine-dependent endothelial dysfunction (53), we examined whether CBs could ameliorate the increase in Cx43 hemichannel activity evoked by IL-1β/TNF-α and high glucose in EAhy cells. This evidence concerns the gene CNR1 and endothelial dysfunction.