In glioma patient tumor specimens, 26% of samples showed CARMA3 overexpression relative to normal astrocytes in the same specimen (125); the authors also showed that CARMA3 knockdown in a glioma cell line suppresses cell invasion in vitro and results in decreased expression of MMP9, a matrix metalloprotease closely linked with tissue invasion. The gene discussed is CARD10; the disease is central nervous system cancer.