Indeed, we found that that AGTR1 overexpression, in both breast cancer patient samples and breast cancer cell lines, drives NF-κB activation and an associated NF-κB gene expression signature; as we expected, CARMA3, Bcl10, and MALT1 are each required for this to occur (Table 1A) (50). The gene discussed is NFKB1; the disease is breast carcinoma.