Recently, TRIM29, a E3 ubiquitin ligase that is highly expressed in the lung alveolar macrophages, is also found to be critical for controlling RNA and DNA virus-triggered airway inflammation by targeting NEMO (IKKγ) and STING, respectively, to attenuate the production of IFN-I and proinflammatory cytokines (54, 55). The gene discussed is STING1; the disease is inflammation.