ZEB1 and familial pancreatic carcinoma: Aberrant activation of EMT has been attributed to over-expression of mesenchymal markers, such as Zeb1 (zinc finger E-box binding homeobox 1) (9), Snail (10), and Vimentin (10), as well as repression of E-cadherin, an epithelial marker (6) in the pancreatic cancer cells.