IFNG and cancer: While the role of type I NKT cells in protection against autoimmunity has been mainly through production of Th2 cytokines like IL-4 and IL-13, their protection against cancer has been found to be largely dependent on production of Th1 cytokines, especially interferon-γ (IFN-γ), even though NKT cells have lytic activity and could potentially directly lyse tumors that express CD1d (53, 54).