We recruited 96 healthy women and 106 women with SSc, quantified sHLA-G in plasma samples from respectively 88 and 74 women by enzyme linked immunosorbent assay (ELISA) and analyzed 8 polymorphisms in the 5′URR and 3′UTR of the HLA-G gene, including the most described 14-bp insertion/deletion to determine UTR1-8 haplotypes. The gene discussed is HLA-G; the disease is systemic sclerosis.