Thus, in the current study we test whether 1/women with SSc display lower sHLA-G levels in their plasma than healthy age-matched women, 2/quantities of persistent fetal Mc in their blood inversely correlate with sHLA-G levels, and 3/sHLA-G levels correlate with HLA-G polymorphisms/haplotypes. Here, HLA-G is linked to systemic sclerosis.