Soluble HLA-G (shed HLA-G1 and sHLA-G5) could be detected by the ELISA technique defined at the “Wet-Workshop for the Quantification of sHLA-G” in all plasma samples (43), with quantities ranging from 8.8 International Units (IU) per mL of plasma to 187.9 IU/mL in samples from women with SSc and from 13.5 to 262.5 IU/mL in samples from healthy women (Figure 1). The gene discussed is HLA-G; the disease is systemic sclerosis.